Section of High Resolution Brain PET Imaging

Director: Dean Foster Wong
John Hopkins School of Medicine

John Hopkins neuroimaging specialists will develop a noninvasive way of measuring human brain neuronal activity and chemical changes in milliseconds as opposed to several minutes, as in current PET scans. The new technique will also be much more sensitive to neurochemical processes than other imaging techniques, including functional magnetic resonance imaging and magnetoencephalographic recording of brain magnetic fields.

Imaging in vivo neurotransmitter modulation

Principal Investigator: Dean Foster Wong
Johns Hopkins University
Title: Imaging in vivo neurotransmitter modulation of brain network activity in realtime
BRAIN Category: Next Generation Human Imaging (RFA MH-14-217)

Dr. Wong and colleagues will explore the possibility that newly developed infrared chemical tags may be used for minimally invasive imaging of rapidly changing human brain chemical messenger activity – with greater time resolution.

NIH Webpages

Single-unit and multi-electrode recording

Single-unit recordings provide a method of measuring the electro-physiological responses of single neurons using a microelectrode system.

When a neuron generates an action potential, the signal propagates down the neuron as a current which flows in and out of the cell through excitable membrane regions in thesoma and axon. A microelectrode is inserted into the brain, where it can record the rate of change in voltage with respect to time.

Skip to toolbar