Dean Foster Wong

Professor, Johns Hopkins Medicine Department of Radiology and Radiological Science
Radiology Vice Chair, Research Administration and Training
Director, Section of High Resolution Brain PET Imaging, Division of Nuclear Medicine

Dr. Wong has used PET scanning to uncover key insights into brain chemistry and to identify receptors for the major neurotransmitters. He oversaw the first dopamine PET receptor imaging in human beings; led the first study suggesting D2 dopamine receptors in schizophrenia, and how dopamine is transported in and out of cells.

Section of High Resolution Brain PET Imaging

Director: Dean Foster Wong
John Hopkins School of Medicine

John Hopkins neuroimaging specialists will develop a noninvasive way of measuring human brain neuronal activity and chemical changes in milliseconds as opposed to several minutes, as in current PET scans. The new technique will also be much more sensitive to neurochemical processes than other imaging techniques, including functional magnetic resonance imaging and magnetoencephalographic recording of brain magnetic fields.

Imaging in vivo neurotransmitter modulation

Principal Investigator: Dean Foster Wong
Johns Hopkins University
Title: Imaging in vivo neurotransmitter modulation of brain network activity in realtime
BRAIN Category: Next Generation Human Imaging (RFA MH-14-217)

Dr. Wong and colleagues will explore the possibility that newly developed infrared chemical tags may be used for minimally invasive imaging of rapidly changing human brain chemical messenger activity – with greater time resolution.

NIH Webpages

Next Generation Human Imaging Grants

This post has links to posts about the Grants, Principal Investigators, the Principal Investigator Labs, and their affiliated Institutions within the Next Generation Human Imaging category (RFA MH-14-217) .

Also in this post, below the links, are short descriptions of each grant.

Magnetic Particle Imaging (MPI)

Principal Investigator: Lawrence Wald
Title: "Magnetic Particle Imaging (MPI) for Functional Brain Imaging in Humans"
BRAIN Category: Next Generation Human Imaging (RFA MH-14-217)

The Wald team plans to use an iron-oxide contrast agent to track blood volume, which will permit dramatically more sensitive imaging of human brain activity than existing methods.

Imaging Brain Function with Portable MRI

Principal Investigator: Michael Garwood
Institute for Translational Neuroscience, University of Minnesta
Title: "Imaging Brain Function in Real World Environments & Populations with Portable MRI"
BRAIN Category: Next Generation Human Imaging (RFA MH-14-217)

By employing smaller, less cumbersome magnets than used in existing MRI, Dr. Garwood and colleagues will create a downsized, portable, less expensive brain scanner.

Advancing MRI & MRS Technologies

Principal Investigator: Wei Chen
Institute for Translational Neuroscience, University of Minnesota
Title: "Advancing MRI & MRS Technologies for Studying Human Brain Function and Energetics"
BRAIN Category: Next Generation Human Imaging (RFA MH-14-217)

Dr. Chen's team will achieve unprecedented higher resolution magnetic resonance imaging and spectroscopy scanning by integrating ultra-high dielectric constant material and ultra-high-field techniques.

MRI Neuro-Electro-Magnetic Oscillations

Principal Investigator: Allen W Song
Duke Institute for Brain Sciences
Title: "Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations"
BRAIN Category: Next Generation Human Imaging (RFA MH-14-217)

Dr. Song's group will develop a scanner technology sensitive enough to image brain activity in high resolution by directly tuning in the electromagnetic signals broadcast by neurons.

Vascular Interfaces for Brain Imaging

PI: Robert Desimone
Massachusetts Institute of Technology
Title: "Vascular Interfaces for Brain Imaging and Stimulation"
BRAIN category: Next Generation Human Imaging (RFA MH-14-217)

Dr. Desimone's project will access the brain through its network of blood vessels to less invasively image, stimulate and monitor electrical and molecular activity than existing methods.

Ultrasonic neuromodulation in vivo

PI: Doris Ying Tsao
California Institute of Technology
Title: "Dissecting human brain circuits in vivo using ultrasonic neuromodulation"
BRAIN category: Next Generation Human Imaging (RFA MH-14-217)

In rodents, monkeys and eventually humans, Dr. Tsao's team will explore use of non-invasive, high resolution ultrasound to impact neural activity deep in the brain and modify behavior.

Micro-Dose, Wearable PET Brain Imager

Principal Investigator: Julie Brefczynski-Lewis
WVU Center for Neuroscience
Title: Imaging the Brain in Motion: The Ambulatory Micro-Dose, Wearable PET Brain Imager
BRAIN Category: Next Generation Human Imaging (RFA MH-14-217)

Dr. Brefczynski-Lewis and co-workers will engineer a wearable PET scanner that images activity of the human brain in motion – for example, while taking a walk in the park.

MRI Corticography (MRCoG)

Principal Investigator: David Alan Feinberg
Helen Wills Neuroscience Institute
Title: "MRI Corticography (MRCoG): Micro-scale Human Cortical Imaging"
BRAIN Category: Next Generation Human Imaging (RFA MH-14-217)

To image the activity and connections of the brain's cortex on a micro scale – with dramatically higher resolution than existing scanners – Dr. Feinberg's group will employ high sensitivity MRI coils that focus exclusively on the brain's surface.

Skip to toolbar